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Dr. Srinivasan on VHL-associated RCC prognosis and treatment
Ramaprasad Srinivasan, MD, PhD, provides background on the prognosis and treatment of patients with Von Hippel-Lindau–associated renal cell carcinoma and highlights the novel agent MK-6482.
Ramaprasad Srinivasan, MD, PhD, Urologic Oncology Branch, National Cancer Institute, provides in-depth background of the prognosis and treatment development for Von Hippel-Lindau (VHL)–associated renal cell carcinoma (RCC).
During the 2020 Society of Urologic Oncology Annual Meeting, Srinivasan shared results from a phase 2 study of the investigational HIF-2α inhibitor MK-6482 in patients with VHL–associated RCC. At a median follow-up of 68.7 weeks (range, 18.3-104.7), the objective response rate in RCC lesions among 60 evaluable patients was 36.1%, comprising 22 confirmed partial responses. There were also 7 unconfirmed PRs. Overall, 91.8% (n = 56) of patients had at least some decrease in the size of target lesions.
Dosing commences in phase 1/2 trial of AB-2100 in ccRCC
May 15th 2024The dose escalation/dose expansion study is evaluating the safety and efficacy of AB-2100 in patients with ccRCC who either came back or did not improve following prior treatment with a checkpoint inhibitor and a VEGF inhibitor.
Grant awarded to aid development of allogeneic CAR T treatment for RCC
April 29th 2024“This clinical study has the potential to demonstrate the value of Chimeric Antigen Receptor (CAR) T cell therapy in solid cancers such as kidney cancer with a high unmet medical need,” said Abla Creasey, PhD.
Updated data show survival benefit with adjuvant pembrolizumab in ccRCC
April 19th 2024“This is the first study to show a statistically significant and clinically meaningful survival improvement with any adjuvant therapy in kidney cancer, and this further supports adjuvant pembrolizumab as a standard of care after surgery in this disease setting,” says Toni K. Choueiri, MD.
Toripalimab plus axitinib approved in China for renal cell carcinoma
April 11th 2024The approval is based on findings from the phase 3 RENOTORCH trial, which showed that toripalimab plus axitinib prolonged progression-free survival and improved the objective response rate in patients with advanced RCC compared with sunitinib.
