Delayed prostatectomy following active surveillance does not affect recurrence

In this video, Kevin Shee, MD, PhD, shares notable findings from the European Urology study “The Impact of Delayed Radical Prostatectomy on Recurrence Outcomes After Initial Active Surveillance: Results from a Large Institutional Cohort.” Shee is a urology resident at the University of California, San Francisco.

Transcription:

What were some of the notable findings from the study?

Just to talk a little bit about our cohort, we had about 1200 men in our study enrolled in our urologic outcomes database at UCSF. We had 979 patients who underwent radical prostatectomy immediately after diagnosis of Gleason grade group 2 cancer, so Gleason grade 3 plus 4. We had 190 patients who had radical prostatectomy after upgrading to basically on active surveillance within 12 months, and then we had 90 patients who got radical prostatectomy greater than 12 months after upgrading while on active surveillance. Initially, in our univariate analysis, it showed that maybe there was a significant difference in the patients that had a 12-month delay in radical prostatectomy after upgrade. But in our multivariate analysis, we actually found that there was no significant difference between the groups. Another aspect of our study that was unique and interesting is, most of the active surveillance data to date hasn't really incorporated a lot of the more recent advances in active surveillance, [such as] prostate MRI, MRI targeted biopsy, and genomic testing. Our study did include those variables, and we actually did not find that those were significantly involved in predicting recurrence. I would say those are all the major findings.

This transcription was edited for clarity.