Herbal extract may suppress PCa cell growth

An herbal extract preparation known as Zyflamend appears to suppress the growth of prostate cancer cells and induces the cells to self-destruct, according to Columbia University researchers. Their study showed that the formulation has the ability, in vitro, to reduce prostate cancer cell proliferation by as much as 78% and appeared to confirm that it has COX-1 and COX-2 anti-inflammatory effects.

“Zyflamend is derived from natural herbal sources and is readily available in health food and nutritional supplement stores,” said lead author Debra L Bemis, MD. “Given the impressive data we’re reporting, Zyflamend is a potentially more convenient and desirable means to target the enormous population that is susceptible to prostate cancer.”

The agent’s anti-cancer effects were independent of COX-2 inhibition, supporting the postulation that some prostate cancer cells are not affected by COX-2 inflammation. Zyflamend’s biochemical action profile resembles aspirin more than selective COX-2 inhibitors, Dr. Bemis said.

On the strength of this laboratory research, the investigators have commenced a phase I human clinical trial testing the therapy’s ability to prevent prostate cancer in patients with prostatic intraepithelial neoplasia.

Study results were published in Nutrition and Cancer (2005; 52:202-12).