The recalcitrant overactive bladder patient

Overactive bladder (OAB), the most prevalent form of urinary incontinence, is due to involuntary contractions of the bladder (detrusor) muscle with symptoms of urinary frequency, urgency, and urge incontinence. Overactive bladder is often managed with pharmacologic intervention that focuses on inhibiting detrusor activity and increasing bladder capacity.

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April 1st 2021

Pivotal data for lumasiran in PH1 published in NEJM

Jason M. Broderick

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April 1st 2021

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February 26th 2021

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Jason M. Broderick

The RNAi drug nedosiran is a once-monthly subcutaneous injection under investigation for all 3 types of primary hyperoxaluria.

February 9th 2021

Enrollment completed in pivotal trial of nedosiran for hyperoxaluria

Jason M. Broderick

FDA new drug application filing expected by the end of 2021.

September 12th 2012

FDA approves androgen inhibitor for metastatic PCa

The FDA recently approved the oral androgen receptor inhibitor enzalutamide (Xtandi) for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel (Taxotere).

August 29th 2012

Blood test could guide treatment for kidney cancer

A common enzyme that is easily detected in blood may predict how well patients with advanced kidney cancer will respond to a specific treatment, according to physicians at Duke Cancer Institute, Durham, NC.

August 22nd 2012

BCG for bladder cancer in short supply

Due to manufacturing issues, a formulation of the bladder cancer treatment bacillus Calmette-Guérin is currently unavailable from one manufacturer.