Treatment advances for overactive bladder 'pushing the therapeutic index'

Chicago-Some researchers investigating the physiology and treatment ofoveractive bladder have questioned whether a "therapeutic ceiling"has been reached with anticholinergic medications, the current mainstayof treatment. Although the balance between efficacy and tolerability ofanticholinergics falls short of ideal, a number of products under developmenthold promise, said Roger Dmochowski, MD, professor of urology at VanderbiltUniversity School of Medicine in Nashville, TN.

Related Videos

Related Content

Advertisement

April 1st 2021

Pivotal data for lumasiran in PH1 published in NEJM

Jason M. Broderick

The ILLUMINATE-A trial of lumasiran in patients with primary hyperoxaluria type 1 supported the FDA approval of this drug.

February 26th 2021

Nedosiran explored in primary hyperoxaluria type 3

Jason M. Broderick

The RNAi drug nedosiran is a once-monthly subcutaneous injection under investigation for all 3 types of primary hyperoxaluria.

February 9th 2021

Enrollment completed in pivotal trial of nedosiran for hyperoxaluria

Jason M. Broderick

FDA new drug application filing expected by the end of 2021.

September 12th 2012

FDA approves androgen inhibitor for metastatic PCa

The FDA recently approved the oral androgen receptor inhibitor enzalutamide (Xtandi) for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel (Taxotere).

August 29th 2012

Blood test could guide treatment for kidney cancer

A common enzyme that is easily detected in blood may predict how well patients with advanced kidney cancer will respond to a specific treatment, according to physicians at Duke Cancer Institute, Durham, NC.

August 22nd 2012

BCG for bladder cancer in short supply

Due to manufacturing issues, a formulation of the bladder cancer treatment bacillus Calmette-Guérin is currently unavailable from one manufacturer.

Related Content

Advertisement

April 1st 2021

Pivotal data for lumasiran in PH1 published in NEJM

Jason M. Broderick

The ILLUMINATE-A trial of lumasiran in patients with primary hyperoxaluria type 1 supported the FDA approval of this drug.

February 26th 2021

Nedosiran explored in primary hyperoxaluria type 3

Jason M. Broderick

The RNAi drug nedosiran is a once-monthly subcutaneous injection under investigation for all 3 types of primary hyperoxaluria.

February 9th 2021

Enrollment completed in pivotal trial of nedosiran for hyperoxaluria

Jason M. Broderick

FDA new drug application filing expected by the end of 2021.

September 12th 2012

FDA approves androgen inhibitor for metastatic PCa

The FDA recently approved the oral androgen receptor inhibitor enzalutamide (Xtandi) for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel (Taxotere).

August 29th 2012

Blood test could guide treatment for kidney cancer

A common enzyme that is easily detected in blood may predict how well patients with advanced kidney cancer will respond to a specific treatment, according to physicians at Duke Cancer Institute, Durham, NC.

August 22nd 2012

BCG for bladder cancer in short supply

Due to manufacturing issues, a formulation of the bladder cancer treatment bacillus Calmette-Guérin is currently unavailable from one manufacturer.