Benign Conditions

Postoperative urinary retention is a common outcome after surgical procedures for pelvic organ prolapse and stress urinary incontinence.

"We have over 30 years of safety data, and no adverse events in over 30 years," says Heather Florio.

Liposomal tacrolimus led to improvements in hematuria, bleeding sites on cystoscopy, microscopic urine analysis for red blood cells, and urinary symptoms.

Questions spanned urologic conditions such as benign prostatic hyperplasia, overactive bladder, erectile dysfunction, kidney stones, Peyronie disease, and recurrent urinary tract infections.

“Men with and without retention all do very well from the voiding standpoint with relatively low rates of complications,” says Claire S. Burton, MD.

"Right now, the longest-term studies are the WATER trials, which have published 5-year outcomes. But we know that a subset of men will require retreatment over time," says Claire S. Burton, MD.

"What we found is that those with acute urinary retention took longer to ultimately pass their trial without a catheter, meaning that they were voiding without the use of any catheterization," says Claire S. Burton, MD.

The multiplex polymerase chain reaction/pooled antibiotic susceptibility test was associated with a 44.4% lower mean total UTI-related cost compared to standard urine culture.

“I would say that these conditions are highly heterogeneous, and we've identified a number of factors that relate to different ways that the disease progresses and different ways that patients feel about the progression of their disease,” says Alisa J. Stephens-Shields, PhD.

The findings suggest creatinine-based eGFR equations alone may be inaccurate, and cystatin C or combined eGFR equations may be a more accurate assessment of kidney function in this population.

Cleveland Clinic surgeons describe a new technique for harvesting a rectal mucosa graft.

“We would like to use all of what we've learned in the MAPP to move back into the space of clinical trials and trying to identify effective therapies for this condition,” says Alisa J. Stephen-Shields, PhD.

“We were a bit surprised that the males with IC/BPS didn't look more like the females with regard to the magnitude of decrease in urinary symptom severity required to feel better,” says Alisa J. Stephens-Shields, PhD.

“As part of the [MAPP] network, and the research that it did, we recognized that it was really important to consider pelvic pain symptoms separately from urinary symptoms,” says Alisa J. Stephens-Shields, PhD.

"It may be something that practicing urologists could already start speaking to their patients about," says Siobhan Sutcliffe, PhD, ScM, MHS.

"We used data from this study to see whether having a greater number of flares independently impacted patients’ quality of life as well as their healthcare seeking activity," said Siobhan Sutcliffe, PhD, ScM, MHS.

The study authors maintain there is no current evidence in the literature indicating that CT use is superior to other imaging modalities in reducing morbidity or improving outcomes in patients with urinary stone disease.

The researchers assessed gender differences in patients with interstitial cystitis/bladder pain syndrome (IC/BPS).

“We observed profound differences in the detection work up and management of chronic kidney disease suggesting suboptimal care among women,” said Juan Jesus Carrero, PharmD, PhD.

"As we look back over the past 5 decades in urology, bladder dysfunction, particularly inadequate contraction, is still a disorder with unmet medical need, for which new treatments are crucial," writes Gopal H. Badlani, MD.

Fluoroquinolone could increase the risk of altered mental status and hospitalizations for older patients with advanced chronic kidney disease.

Addressing the gaps in health literacy may lead to improvement in health outcomes and health care disparities among patients with chronic pelvic pain.

Elisabeth M. Sebesta, MD, coauthor of a recent study, reported that patients who experienced more unmet social needs were at increased risk of multiple urologic conditions, such as overactive bladder, interstitial cystitis, or urge incontinence.

In this interview, Andrea Staack, MD, PhD, discusses the background, findings, and takeaways of the study, "Mindfulness based-stress reduction is associated with decreased levels of patients’ anxiety after urodynamics- A prospective randomized controlled trial," along with why urologists should consider implementing more strategies of this effect in their practices.

In this interview, Ashley Winter, MD, discusses why urologists should play a role in the management of STDs and STIs, especially when it comes to destigmatizing them.

"Certainly, the Optilume drug-coated balloon appears to be safe and effective in roughly two-thirds of patients at 3 years," said Justin Chee, MD.

“Optilume exhibited a significant improvement in [the primary] objective outcome at 6 months and subjective outcomes at 1-year post treatment compared to standard of care,” said Justin Chee, MBBS, FRACS.

In the pivotal phase 3 DAPA-CKD trial, dapagliflozin reduced the relative risk of worsening of renal function, onset of end-stage kidney disease, or cardiovascular or renal death by 39%.

The FDA’s decision not to approve roxadustat follows a vote from the agency’s Cardiovascular and Renal Drugs Advisory Committee that the drug’s benefit-risk profile does not support approval.

The FDA has issued a complete response letter regarding a new drug application for tenapanor for the control of serum phosphorus in adult patients with chronic kidney disease on dialysis.