A Summary of Clinical Challenges and an Introduction to Focal Therapy

Insights on the drawbacks of older treatment approaches for clinically localized prostate cancer and how strategically implementing focal therapies may address remaining unmet needs and clinical challenges.

EP: 1.The Diagnostic Journey of Prostate Cancer: Common Tests and Procedures Used in the US and UK

EP: 2.Prostate Cancer Staging, Incidence of Clinically Localized Disease, and Patient Risk Stratification

EP: 3.A Historical Perspective on Treatment Options for Localized Prostate Cancer

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EP: 4.A Summary of Clinical Challenges and an Introduction to Focal Therapy

EP: 5.Available Focal Therapy Options for Localized Prostate Cancer

EP: 6.Safety and Efficacy Data Supporting the Use of Focal Therapy in Patients with Prostate Cancer

EP: 7.Global Perspective: The Adoption of Focal Therapy in the US and UK

EP: 8.The Impact of Focal Therapy on Prostate Cancer Treatment Paradigms and Patient Outcomes

EP: 9.Prevention and Mitigation of Focal Therapy-Related Side Effects

EP: 10.Follow-up Considerations for Patients Receiving Focal Therapy

EP: 11.Exciting Prospects for the Future of Localized Prostate Cancer Treatment

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Urology Times staff

In this podcast episode, Adam B. Murphy, MD, MBA, MSCI, discusses the need to increase diversity in clinical trials, specifically focusing on studies in prostate cancer.

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"Efficacy outcomes with darolutamide plus ADT were improved vs placebo plus ADT regardless of disease volume," said Fred Saad, MD, FRCS.

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Zeyad Schwen, MD, a urologic oncologist at Cleveland Clinic, discusses how patient factors and cancer characteristics are key to deciding between focal therapies and whole gland treatment for prostate cancer.

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"Patients with metastatic hormone-sensitive prostate cancer benefited from treatment with darolutamide plus ADT and docetaxel regardless of age," said Joan Carles, MD, PhD.

February 13th 2025

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In both racial cohorts, median MFS was not reached in the darolutamide group.