Opinion

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Intravesical Novel Therapy for HR BCG-Unresponsive NMIBC

Author(s):

Gary Steinberg, MD, FACS

Gary D. Steinberg, MD, analyzes data from the BOND-003 study presented at AUA 2024, which investigated the use of intravesical cretostimogene grenadenorepvec for treating high-risk, BCG-unresponsive non-muscle invasive bladder cancer with carcinoma in situ, and discusses the mechanism of action of this novel oncolytic viral therapy.

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      Video content above is prompted by the following question(s):

      • Interim data from BOND-003 were just recently presented during the AUA 2024: (A Phase 3, Single-arm Study of Intravesical Cretostimogene Grenadenorepvec for the Treatment of High Risk, BCG-Unresponsive Non-Muscle Invasive Bladder Cancer with Carcinoma in Situ).
        • What is the mechanism of action of cretostimogene?
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