Exploring Treatments for BCG-Unresponsive Intermediate-High Risk NMIBC

Expert urologist explores potential treatments for BCG-unresponsive intermediate and high-risk non-muscle-invasive bladder cancer (NMIBC), including immune checkpoint inhibitors, oncolytic viral therapy, cytokine agonists, immunomodulators, and the recently approved drugs pembrolizumab and nogapendekin alfa inbakicept-pmln.

EP: 1.Unmet Needs & Standard of Care for Intermediate-High Risk NMIBC

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EP: 2.Exploring Treatments for BCG-Unresponsive Intermediate-High Risk NMIBC

EP: 3.Intravesical Novel Therapy for HR BCG-Unresponsive NMIBC

EP: 4.AUA 2024: Outlining BOND-003 Data for NMIBC Therapy

EP: 5.BOND-003: Clinical Implications for HR BCG-Unresponsive NMIBC Treatment

EP: 6.AUA 2024: Key Takeaways & Future of NMIBC Management

1. Can you discuss some of the exploratory treatments for BCG‐unresponsive intermediate and high risk‐NMIBC? (eg. immune checkpoint inhibitors (ICI), oncolytic viral therapy, cytokine agonists, and other immunomodulators)
2. BCG‐unresponsiveness (definition?)
   1. Include (recently) approved immunotherapies: pembrolizumab, nogapendekin alfa inbakicept-pmln
3. Gene therapy: nadofaragene firadenovec

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