PSA doubling time: Solid predictor of PCa survival
August 1st 2004New Orleans--PSA doubling time (PSADT) appears to be a strong predictor of the probability of distant metastasis and prostate cancer-specific survival in men with biochemical relapse after radical prostatectomy, according to Mario A. Eisenberger, MD.
What role will stem cells play in male infertility?
August 1st 2004The use of stem cells to treat otherwise incurable or serious human disease remains a political "hot potato." One must remember, however, that the sources of embryonic and adult stem cells are distinctly different. The use of adult stem cells avoids all of the ethical and political criticism associated with the former's fetal etiology. While not totipotential, adult stem cells still have the advantage of prolonged proliferation, self-renewal, generation of more differentiated cells, maintenance of developmental potential, and proliferation in response to injury.
Varicocelectomy results improve with microsurgery
August 1st 2004San Francisco--The microsurgical approach is an effective method for varicocele repair in adolescents and offers the advantages of lower rates of persistence, recurrence, and hydrocele formation than alternative methods, according to the findings of two independent studies presented at the AUA annual meeting.
Prostatitis carries a high price--in more ways than one
August 1st 2004Chronic prostatitis carries a high price-both on the health care system and society in general. Two separate studies demonstrate those costs may be 1.7 times higher than for men without prostatitis and perhaps 1.5 times higher than for another debilitating chronic pain syndrome, rheumatoid arthritis.
Antiandrogen/castration may reduce death risk by 20%
August 1st 2004New Orleans--Bicalutamide (Casodex), 50 mg, plus castration leads to an estimated 20% reduction in risk of prostate cancer death versus castration alone, according to results of a historical data analysis presented at the annual of the American Society of Clinical Oncology meeting here.
IC pain perception unaltered by pH neutralization
August 1st 2004San Francisco--Results from a study evaluating the effect of urinary pH alteration in patients with interstitial cystitis suggest little benefit is likely gained from alkalinizing the urine to a neutral pH. Nevertheless, the question of how urine pH affects IC symptoms remains unanswered and requires further study, concluded the authors, from the University of British Columbia, Vancouver.
Antidepressant reduces overall symptoms of IC
August 1st 2004San Francisco--The tricyclic antidepressant amitriptyline (Elavil) is a safe and effective treatment for interstitial cystitis with significant benefits for reducing overall symptoms along with pain and urgency, according to the results of a German study.
Clinical factors predict metastatic progression post-RP
August 1st 2004New Orleans--A combination of common clinical factors can accurately predict which patients who have biochemical failure after radical prostatectomy are likely to develop metastatic progression, said investigators from Memorial Sloan-Kettering Cancer Center, New York.
Rapid PSA rise may point to high risk of prostate cancer death
July 23rd 2004Men whose PSA level increases by more than 2.0 ng/mL during the year prior to a prostate cancer diagnosis may have a relatively high risk of future cancer death even if they undergo radical prostatectomy, according to a recent report in the New England Journal of Medicine (2004; 351:125-35).