Exploring NMIBC: Overview, Symptoms, Risk Factors and Staging

Author(s):

Félix Guerrero-Ramos, MD, PhD, FEBU ,Srikala Sridhar, MD

Key Takeaways

NMIBC is defined by tumors not invading the bladder muscle layer, with symptoms like hematuria and dysuria.
Diagnostic confirmation involves cystoscopy, urine cytology, and imaging studies.
The economic burden of NMIBC is substantial due to ongoing surveillance and treatment expenses.
Smoking and occupational exposures are primary risk factors, with no definitive genetic links identified.
Accurate staging is essential for effective treatment, as misclassification can adversely affect patient management.

Panelists discuss how non–muscle-invasive bladder cancer (NMIBC) presents with specific symptoms and diagnostic procedures, emphasize the significant economic burden on health care systems, and highlight key risk factors like smoking and occupational exposure while also addressing the critical importance of accurate staging for guiding treatment decisions and the potential consequences of incorrect staging on patient outcomes.

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EP: 1.Exploring NMIBC: Overview, Symptoms, Risk Factors and Staging

EP: 2.NMIBC Treatment Insights: Standard of Care, BCG Immune Response, and Patient Outcomes

EP: 3.Exploring PD-1/PD-L1 Pathways and Innovative Treatments for NMIBC

EP: 4.Innovations in NMIBC Treatment: The Synergy of BCG and PD-1/PD-L1 Inhibitors

EP: 5.Collaborative Strategies: Urologists and Oncologists Enhancing Outcomes for High-Risk NMIBC

EP: 6.Navigating PD-1/PD-L1 Agents: Influential Factors in Choosing the Right Therapy

EP: 7.Phase 3 Trials of PD-1/PD-L1 Inhibitors in NMIBC

EP: 8.Examining the Effects of PD-1/PD-L1 Inhibitor Differences on Patient Outcomes: Adherence, BCG Maintenance, and Resource Management

EP: 9.Exploring Emerging Data in NMIBC

EP: 10.Optimizing Multidisciplinary Care for BCG-Naive, High-Risk NMIBC

Video content above is prompted by the following:

What is non–muscle-invasive bladder cancer (NMIBC)?
What are the common symptoms and signs of NMIBC?
What diagnostic procedures are typically used to confirm a case of NMIBC?
What is the economic burden of this disease for health care systems and insurance companies?

What are the main risk factors associated with the development of NMIBC? Grabe-Heyne 2023
Smoking as a risk factor for the development of bladder cancer
Occupational risk factors
No clear genetic association (that we know of so far)

What are the different stages and grades of NMIBC?Grabe-Heyne 2023
What is the importance of getting the stage correct? (PMID 38994181)
Ensuring appropriate treatment based on patient stage
How often do you feel that patients are incorrectly staged? How does that then affect the patient treatment journey?