Opinion

Video

Genetic Testing in Metastatic Prostate Cancer: Key Insights on Germline and Somatic Mutations

Author(s):

Pedro Barata, MD, MSc, FACP

Key Takeaways

  • Talazoparib in the TALAPRO-1 trial improved progression-free survival and overall response rates in metastatic prostate cancer with specific genetic alterations.
  • Rucaparib in the TRITON3 trial showed superior progression-free survival compared to standard treatments, highlighting its efficacy in targeted patient populations.
SHOW MORE

Panelists discuss how PARP inhibitor monotherapy trials like TALAPRO-1 (talazoparib) and TRITON-3 (rucaparib) have demonstrated efficacy and safety in treating metastatic prostate cancer patients with homologous recombination repair gene alterations, providing important insights into targeted therapy options for this specific patient population.

Video Content above is prompted by the following:

  • Discuss efficacy and safety findings from monotherapy trials of PARP inhibitors in metastatic prostate cancer harboring homologous recombination repair (gene alterations.
    • TALAPRO-1 trial (talazoparib), NCT03148795
    • TRITON3 trial (rucaparib), NCT02975934.
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