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Deep Data Dive: Highlights From ASCO 2024 on the Treatment of High-Risk BCG-Unresponsive NMIBC

Video Series

Prevalence and Staging of Newly Diagnosed Bladder Cancer

Video content above is prompted by the following:

Of patients with newly diagnosed bladder cancer, approximately how many have non-muscle invasive bladder cancer, or NMIBC?

Can you briefly describe the stages of bladder cancer, and how frequently are patients diagnosed with metastatic disease at time of diagnosis?

Videos

Trinity Bivalacqua, MD, PhD, and Mark Tyson, MD, MPH, discuss key conversation points surrounding high-risk BCG-unresponsive NMIBC as presented at ASCO 2024 in Chicago, Illinois.

After briefly introducing themselves, Trinity Bivalacqua, MD, PhD and Mark Tyson, MD, MPH discuss approximately how many newly diagnosed bladder cancer patients have non-muscle invasive bladder cancer, or NMIBC.

Trinity Bivalacqua, MD, PhD and Mark Tyson, MD, MPH discuss the current shortage of BCG therapy and how that has impacted clinical practice management.

Impact of BCG Therapy Shortage on the Management of High-Risk NMIBC

Experts discuss the rate of recurrence following first-line BCG therapy.

Recurrence and BCG Resistance in High-Risk NMIBC

Experts discuss available therapies beyond BCG.

Therapies Beyond BCG: FDA-Approved and Emerging Options

Experts give an overview of the ASCO 2024 data. 

Cretostimogene, Grenadenorepvec, and Pembrolizumab for BCG-Unresponsive NMIBC: Overview of ASCO 2024 Data

Experts discuss the patient quantity and qualifications for the CORE-001 trial.

CORE-001 Trial Participation and Eligibility Criteria

Experts compare Cretostimogene and BCG Administration Methods

Comparing Cretostimogene and BCG Administration Methods

Experts discuss the results of the CORE-001 Trial. 

Results of the CORE-001 Trial: 24-Month Complete Response Rate and Duration of Response

Key opinion leaders examine the comparative safety profiles and response durations of combination therapy versus monotherapy in the treatment of BCG-unresponsive carcinoma in situ with or without papillary disease.

Safety Outcomes and Duration of Response in Combination Therapy vs. Monotherapy for BCG UR CIS +/- Papillary Disease

Panelists discuss how the combination therapy of cretostimogene plus pembrolizumab offers a promising new approach for managing BCG-unresponsive non-muscle-invasive bladder cancer, highlighting its potential benefits and the implications of its FDA Breakthrough Therapy Designation for clinical practice.

Evaluating the Benefits of Cretostimogene Plus Pembrolizumab for BCG-Unresponsive NMIBC Management

Panelists discuss whether the trial results support investigating cretostimogene with other checkpoint inhibitors and provide insights into notable ongoing trials exploring cretostimogene for intermediate- or high-risk NMIBC, such as BOND-003 and PIVOT-006.

Evaluating Cretostimogene: BOND-003 and PIVOT-006 Trial Results

Panelists discuss their views on using cretostimogene as monotherapy versus combination therapy, the importance for urologists to stay updated on advances for managing BCG-unresponsive NMIBC, and the potential impact of combining cretostimogene with pembrolizumab on addressing unmet needs in NMIBC care.

Managing BCG-Unresponsive NMIBC: Cretostimogene Monotherapy vs. Combination Therapy

Prevalence and Staging of Newly Diagnosed Bladder Cancer

EP: 1.Prevalence and Staging of Newly Diagnosed Bladder Cancer

EP: 2.Impact of BCG Therapy Shortage on the Management of High-Risk NMIBC

EP: 3.Recurrence and BCG Resistance in High-Risk NMIBC

EP: 4.Therapies Beyond BCG: FDA-Approved and Emerging Options

EP: 5.Cretostimogene, Grenadenorepvec, and Pembrolizumab for BCG-Unresponsive NMIBC: Overview of ASCO 2024 Data

EP: 6.CORE-001 Trial Participation and Eligibility Criteria

EP: 7.Comparing Cretostimogene and BCG Administration Methods

EP: 8.Results of the CORE-001 Trial: 24-Month Complete Response Rate and Duration of Response

EP: 9.Safety Outcomes and Duration of Response in Combination Therapy vs. Monotherapy for BCG UR CIS +/- Papillary Disease

EP: 10.Evaluating the Benefits of Cretostimogene Plus Pembrolizumab for BCG-Unresponsive NMIBC Management

EP: 11.Evaluating Cretostimogene: BOND-003 and PIVOT-006 Trial Results

EP: 12.Managing BCG-Unresponsive NMIBC: Cretostimogene Monotherapy vs. Combination Therapy