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Unresponsive NMIBC: Gene Therapies

Key Takeaways

  • Targeted gene therapy personalizes treatment for BCG-unresponsive NMIBC, improving efficacy and minimizing systemic side effects by focusing on specific genetic mutations.
  • Gene therapies that do not require specialized equipment, such as biosafety hoods, simplify administration and reduce logistical burdens on clinics.
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Katie S. Murray, DO, discusses how the introduction of targeted gene therapies has shifted the approach to managing BCG-unresponsive non–muscle-invasive bladder cancer (NMIBC), offering more personalized treatment options, and explains how the ease of administration—without the need for specialized equipment like biosafety hoods—reduces logistical burdens on clinics.

  1. How has the introduction of targeted gene therapy changed the way you approach managing BCG-unresponsive NMIBC?
  2. Newer gene therapies may not require specialized equipment, such as biosafety hoods, for administration. How does this ease the burden on clinics?
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